Advisor(s)
Bethany Perez-White, Northwestern University Feinberg School of Medicine
Location
Room Café
Start Date
26-4-2019 1:40 PM
End Date
26-4-2019 2:05 PM
Abstract
Epidermal differentiation involves complex signal transduction networks. Often, these signal relays depend on the transmission of cues from the plasma membrane to the nucleus to control gene expression. Receptor tyrosine kinases (RTKs) are integral in orchestrating intracellular communication cascades to induce differentiation. Loss of EphA2 RTK causes differentiation defects in 3D reconstituted human skin (3D RHS) resulting in tight junction catastrophe. In EphA2-deficient (shEphA2) 3D RHS we show significant loss (>75%, P
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Loss of EphA2 inhibits GATA-3 transcriptional function leading to a terminal differentiation defect
Room Café
Epidermal differentiation involves complex signal transduction networks. Often, these signal relays depend on the transmission of cues from the plasma membrane to the nucleus to control gene expression. Receptor tyrosine kinases (RTKs) are integral in orchestrating intracellular communication cascades to induce differentiation. Loss of EphA2 RTK causes differentiation defects in 3D reconstituted human skin (3D RHS) resulting in tight junction catastrophe. In EphA2-deficient (shEphA2) 3D RHS we show significant loss (>75%, P