Session III

The wood in a tree consists of specialized cells, known as vessels, which take water from the roots and transport it to the leaves. The size and density of these vessels can indicate the ability of the tree to transport water, and oak vessels are larger in the early part of the wood, called the earlywood, than vessels grown ... Read More

The Large Synoptic Survey Telescope (LSST) is an 8.4 m telescope in Chile. It will observe ~37 billion objects in the night sky and, of these objects, more than 20 million will exhibit significant brightness variations, known as variable stars. Efficient algorithms are needed to classify the different categories of variable stars to better understand different aspects of Astrophysics. ... Read More

Epidermal Growth Factor Receptor (EGFR) is a transmembrane protein involved in the regulation of signaling pathways and is known to be frequently overexpressed in epithelial tumors. Erlotinib is a small molecule inhibitor of EGFR commonly used for the treatment of lung and pancreatic cancers. In the present study, 707 selective inhibitors of EGFR were designed based on the erlotinib prototype. ... Read More

The study of autophagy is a growing field that is emerging as one of the most important studies in cancer due to the nature of autophagy’s significant biological functions. The complex relationship between autophagy and prostate cancer is still under debate, with studies demonstrating inconsistent results in terms of tumor growth. DNA methylation is one of the key dynamic epigenetic ... Read More

Epidermal differentiation involves complex signal transduction networks. Often, these signal relays depend on the transmission of cues from the plasma membrane to the nucleus to control gene expression. Receptor tyrosine kinases (RTKs) are integral in orchestrating intracellular communication cascades to induce differentiation. Loss of EphA2 RTK causes differentiation defects in 3D reconstituted human skin (3D RHS) resulting in tight junction ... Read More

In this project, we look at the Special Orthogonal group of 3x3 matrices over a finite field, denoted SO(3,p). In particular, we focus on classifying the generalized symmetric spaces, which are defined by an involution f:SO3,pSO3,p such that ffM=M

for these matrices. We begin by explaining what types of involutions exist for our group, and once those involutions are ... Read More

Deubiquitinases (DUBs) are crucial determinants of protein stability, localization, complex formation and activity within cells (1). The OTUD6B DUB has been previously linked to cell growth and proliferation (2). More specifically, the isoform OTUD6B-2 may promote protein synthesis and DNA synthesis through deubiquitination of c-Myc (2). We established OTUD6B-knockout A549 and H1299 non-small cell lung cancer (NSCLC) cell lines to ... Read More

One of the largest improvements in the diagnosis of Alzheimer's disease (AD) has been the use of in vivo imaging methods on various species to detect the presence of amyloid fibrils. However later studies have shown that these fibrils are not closely linked to the development of the disease. Current research suggests that early stage biomarkers which instigate memory ... Read More

Alzheimer’s Disease (AD) and Osteoporosis are common degenerative diseases of aging. AD has been considered a risk for osteoporosis and previous studies have shown that patients with AD have an increased risk for hip fractures which are the result of osteoporosis, suggesting a link between reduced bone mass and AD. This experiment studied the 5xFAD mouse model which recapitulates many ... Read More

To search for the hypothesized SUSY particles, physicists have to create algorithms or cuts to separate signals from the unwanted background events. Cuts are easy to apply to a dataset, but are not always very efficient at selecting the signal being analyzed. In this study, we analyzed the plausibility and effectiveness of using ISR jet pseudorapidity and ISR jet Pt ... Read More