IMSAloquium 2019 Event Schedule

Registration ........ 8:00a.m. – 8:45a.m. . .. Front Entrance

Keynote .............. 9:00a.m. – 9:40a.m. . .. Auditorium

Project Presentations (10 min. + 5 min. Q & A)

Session I....... 9:45a.m. – 10:40a.m. . . A-B Wing Classrooms, IN2
9:45a.m. - 10:00a.m.
10:05a.m. - 10:20a.m.
10:25a.m. - 10:40a.m.

Session II ...... 10:45a.m. – 11:40a.m. ... A-B Wing Classrooms, IN2
10:45a.m. - 11:00a.m.
11:05a.m. - 11:20a.m.
11:25a.m. - 11:40a.m.

Lunch ................. 11:45a.m. – 12:45p.m. ... West Gym

Poster Display ... 12:50p.m. – 1:30p.m. ... Main Gym

Project Presentations (20 min. + 5 min. Q & A)

Session III .... 1:40p.m – 2:35p.m. ......
Ac Pit / B206-Lecture Hall / C200-Library / Café / Math Study / IN2
1:40p.m. - 2:05p.m.
2:10p.m. - 2:35p.m.

Schedule

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2019
Friday, April 26th
1:40 PM

A Novel Classification Method of Hybrid Proton PBS Plans using DVH based Metrics

Louise Lima, Illinois Mathematics and Science Academy
Alice Liu, Illinois Mathematics and Science Academy

Room IN2

1:40 PM - 2:05 PM

Proton Pencil-Beam Scanning treatment plans are optimized using Single-Field Uniform Dose (SFUD), Multi-Field Optimization (MFO), or a combination of the two techniques into a Hybrid plan. In this study, we develop a method to evaluate plans using metrics applied to field-specific differential dose volume histograms (DVHs) from various treatment areas.

An application was developed to create normalized differential DVHs ... Read More

Anatomical Tradeoffs in xylem characteristics impact oak water use strategies

Jessica Oros, Illinois Mathematics and Science Academy

Room Academic Pit

1:40 PM - 2:05 PM

The wood in a tree consists of specialized cells, known as vessels, which take water from the roots and transport it to the leaves. The size and density of these vessels can indicate the ability of the tree to transport water, and oak vessels are larger in the early part of the wood, called the earlywood, than vessels grown ... Read More

Classifying Variable Stars with Gaia Color-Magnitude Diagrams

Xander Hall, Illinois Mathematics and Science Academy

Room Math Study Area

1:40 PM - 2:05 PM

The Large Synoptic Survey Telescope (LSST) is an 8.4 m telescope in Chile. It will observe ~37 billion objects in the night sky and, of these objects, more than 20 million will exhibit significant brightness variations, known as variable stars. Efficient algorithms are needed to classify the different categories of variable stars to better understand different aspects of Astrophysics. ... Read More

Discovery of EGFR using Erlotinib prototype for the Treatment of Lung and Other Cancers

Jodie Meng '20, Illinois Mathematics and Science Academy

Room Library

1:40 PM - 2:04 PM

Epidermal Growth Factor Receptor (EGFR) is a transmembrane protein involved in the regulation of signaling pathways and is known to be frequently overexpressed in epithelial tumors. Erlotinib is a small molecule inhibitor of EGFR commonly used for the treatment of lung and pancreatic cancers. In the present study, 707 selective inhibitors of EGFR were designed based on the erlotinib prototype. ... Read More

DNA Methylation in Autophagy-associated Genes and Risk of Prostate Cancer

Jimmy Ren, Illinois Mathematics and Science Academy

Room Lecture Hall

1:40 PM - 2:05 PM

The study of autophagy is a growing field that is emerging as one of the most important studies in cancer due to the nature of autophagy’s significant biological functions. The complex relationship between autophagy and prostate cancer is still under debate, with studies demonstrating inconsistent results in terms of tumor growth. DNA methylation is one of the key dynamic epigenetic ... Read More

Loss of EphA2 inhibits GATA-3 transcriptional function leading to a terminal differentiation defect

Michelle Sia, Illinois Mathematics and Science Academy
Amit Somalwar, Illinois Mathematics and Science Academy

Room Café

1:40 PM - 2:05 PM

Epidermal differentiation involves complex signal transduction networks. Often, these signal relays depend on the transmission of cues from the plasma membrane to the nucleus to control gene expression. Receptor tyrosine kinases (RTKs) are integral in orchestrating intracellular communication cascades to induce differentiation. Loss of EphA2 RTK causes differentiation defects in 3D reconstituted human skin (3D RHS) resulting in tight junction ... Read More

2:10 PM

Cell Specific Pallidal Control of Cortical Striatal Input

Shubha Verma, Illinois Mathematics and Science Academy

Room IN2

2:10 PM - 2:35 PM

The basal ganglia are a collection of brain nuclei involved in sequenced movements as well as learning goal-directed behaviors, but it is poorly understood. I researched the inhibitory pathway between the external globus pallidus (GPe) and the dorsal striatum (dStr). Over 95% of the cells composing the striatum are of two classes: direct pathway SPNs (dSPNS) or indirect pathway SPNs ... Read More

Classifying Generalized Symmetric Spaces for Unipotent and Semisimple Elements in SO(3,p)

Hanson Hao, Illinois Mathematics and Science Academy
Jake Sutter, Illinois Mathematics and Science Academy

Room Math Study Area

2:10 PM - 2:35 PM

In this project, we look at the Special Orthogonal group of 3x3 matrices over a finite field, denoted SO(3,p). In particular, we focus on classifying the generalized symmetric spaces, which are defined by an involution f:SO3,pSO3,p such that ffM=M

for these matrices. We begin by explaining what types of involutions exist for our group, and once those involutions are ... Read More

CRISPR knockout of the DUB OTUD6B in lung cancer cells

Nayonika Roy, Illinois Mathematics and Science Academy
Miriam Franks, Illinois Mathematics and Science Academy
Suhitha Irukulla, Illinois Mathematics and Science Academy

Room Academic Pit

2:10 PM - 2:35 PM

Deubiquitinases (DUBs) are crucial determinants of protein stability, localization, complex formation and activity within cells (1). The OTUD6B DUB has been previously linked to cell growth and proliferation (2). More specifically, the isoform OTUD6B-2 may promote protein synthesis and DNA synthesis through deubiquitination of c-Myc (2). We established OTUD6B-knockout A549 and H1299 non-small cell lung cancer (NSCLC) cell lines to ... Read More

Diagnostic Imaging and Therapy of Amyloid Beta Oligomers

Nafay Abdul '20, Illinois Mathematics and Science Academy
Sophia Pribus '20, Illinois Mathematics and Science Academy

Room Café

2:10 PM - 2:35 PM

One of the largest improvements in the diagnosis of Alzheimer's disease (AD) has been the use of in vivo imaging methods on various species to detect the presence of amyloid fibrils. However later studies have shown that these fibrils are not closely linked to the development of the disease. Current research suggests that early stage biomarkers which instigate memory ... Read More

The Pathological Interaction Between Alzheimer’s Disease and Osteoporosis in 5xFAD Model

Shruti Shakthivel, Illinois Mathematics and Science Academy

Room Lecture Hall

2:10 PM - 2:35 PM

Alzheimer’s Disease (AD) and Osteoporosis are common degenerative diseases of aging. AD has been considered a risk for osteoporosis and previous studies have shown that patients with AD have an increased risk for hip fractures which are the result of osteoporosis, suggesting a link between reduced bone mass and AD. This experiment studied the 5xFAD mouse model which recapitulates many ... Read More

Using Initial State Radiation (ISR) Jets for SUSY Search

Emily Sallenback, Illinois Mathematics and Science Academy
Bert Cao, Illinois Mathematics and Science Academy

Room Library

2:10 PM - 2:35 PM

To search for the hypothesized SUSY particles, physicists have to create algorithms or cuts to separate signals from the unwanted background events. Cuts are easy to apply to a dataset, but are not always very efficient at selecting the signal being analyzed. In this study, we analyzed the plausibility and effectiveness of using ISR jet pseudorapidity and ISR jet Pt ... Read More