Advisor(s)

Dr. Ryan Ross, Rush University

Location

Room Lecture Hall

Start Date

26-4-2019 2:10 PM

End Date

26-4-2019 2:35 PM

Abstract

Alzheimer’s Disease (AD) and Osteoporosis are common degenerative diseases of aging. AD has been considered a risk for osteoporosis and previous studies have shown that patients with AD have an increased risk for hip fractures which are the result of osteoporosis, suggesting a link between reduced bone mass and AD. This experiment studied the 5xFAD mouse model which recapitulates many AD-related phenotypes. The objective was to compare the bone mass of 5xFAD mice with AD-like phenotypes to mice without AD. The results demonstrate that 5xFAD mice have a progressive loss of bone mass as they age. Although previous papers have denoted similar results in another AD mouse model, Tg2576, this is the first time these results were shown in the 5xFAD mouse model. As each mouse model of AD recapitulates a different aspect of the disease, these findings can help narrow down what connects osteoporosis and AD. The findings confirm that AD mice have significantly reduced bone mass, consistent with the development of osteoporosis. The substantial change in bone mass over time between the 5xFAD mice and Wild-Type mice suggests that the disease’s effects are age-dependent.

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Apr 26th, 2:10 PM Apr 26th, 2:35 PM

The Pathological Interaction Between Alzheimer’s Disease and Osteoporosis in 5xFAD Model

Room Lecture Hall

Alzheimer’s Disease (AD) and Osteoporosis are common degenerative diseases of aging. AD has been considered a risk for osteoporosis and previous studies have shown that patients with AD have an increased risk for hip fractures which are the result of osteoporosis, suggesting a link between reduced bone mass and AD. This experiment studied the 5xFAD mouse model which recapitulates many AD-related phenotypes. The objective was to compare the bone mass of 5xFAD mice with AD-like phenotypes to mice without AD. The results demonstrate that 5xFAD mice have a progressive loss of bone mass as they age. Although previous papers have denoted similar results in another AD mouse model, Tg2576, this is the first time these results were shown in the 5xFAD mouse model. As each mouse model of AD recapitulates a different aspect of the disease, these findings can help narrow down what connects osteoporosis and AD. The findings confirm that AD mice have significantly reduced bone mass, consistent with the development of osteoporosis. The substantial change in bone mass over time between the 5xFAD mice and Wild-Type mice suggests that the disease’s effects are age-dependent.

 

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