Materials and Methods for Identifying the Efficacy of Curcumin and Boswellia Serrata in Treating Glioblastoma Multiforme
Session Number
Project ID: MEDH 17
Advisor(s)
Dr. Sowmya Anjur; Illinois Mathematics and Science Academy
Discipline
Medical and Health Sciences
Start Date
22-4-2020 10:05 AM
End Date
22-4-2020 10:20 AM
Abstract
Indian frankincense has been used for decades as an anti-inflammatory agent to treat various chronic inflammatory diseases. This plant, in conjunction with radiation therapy, has been found to prevent cellular proliferation, induce apoptosis, and reduce the size of tumors. Turmeric (Curcumin), before being tested on GBM, already had beneficial effects. Though it is not a treatment on it’s own, it works to rid a GBM’s resistance towards certain treatments, like Temozolomide. We have seeded U87 cells in plates and created serial dilutions of the treatment to determine concentration necessary to kill 100% of cells and 50% of cells. After infusing the cancer cells with our indian frankincense treatment, we determined the percentage of cells that died and continued narrowing down the concentration until the proper dosage has been determined. Future plans include testing the effects of resveratrol, icarian, and bittersweet. All of which are natural ingredients that have been observed to have a positive effect on glioblastoma multiforme
Materials and Methods for Identifying the Efficacy of Curcumin and Boswellia Serrata in Treating Glioblastoma Multiforme
Indian frankincense has been used for decades as an anti-inflammatory agent to treat various chronic inflammatory diseases. This plant, in conjunction with radiation therapy, has been found to prevent cellular proliferation, induce apoptosis, and reduce the size of tumors. Turmeric (Curcumin), before being tested on GBM, already had beneficial effects. Though it is not a treatment on it’s own, it works to rid a GBM’s resistance towards certain treatments, like Temozolomide. We have seeded U87 cells in plates and created serial dilutions of the treatment to determine concentration necessary to kill 100% of cells and 50% of cells. After infusing the cancer cells with our indian frankincense treatment, we determined the percentage of cells that died and continued narrowing down the concentration until the proper dosage has been determined. Future plans include testing the effects of resveratrol, icarian, and bittersweet. All of which are natural ingredients that have been observed to have a positive effect on glioblastoma multiforme