The Context-dependent Effects of Fiber Fermentaon on Klebsiella Pneumonia Suppression
Session Number
BIO 08
Advisor(s)
Margaret Carroll, University of Chicago
Discipline
Biology
Start Date
17-4-2024 10:25 AM
End Date
17-4-2024 10:40 AM
Abstract
The gut-microbiome is a crucial part of the human digestive system, responsible for the regulation of metabolism as well as the immune system. Fiber and high fiber diets have been researched to understand their correlation with the health of the gut-microbiome. However, recent findings have shown that fiber can have additional health effects, such as inflammation, in certain populations (Wastyk et al., 2021). This unexpected result may stem from variations in individual microbiomes, influencing its interactions with dietary fibers and its resulting gut composition.
The Raman lab investigates creating diverse microbial communities in different metabolic backgrounds to define functional relationships. Their model focuses on engineered bacterial communities targeting the anbiotic-resistant pathogen, Klebsiella pneumoniae (Oliveira et al., 2024). I am working to investigate a small part of this process, specifically how dietary fiber influences microbial community function, hypothesizing that fiber fermentation varies based on metabolic background.
In the experiment, Klebsiella pneumoniae is cultured in five unique commensal gut strains, with several media conditions supplemented with various fibers. In reviewing the Klebsiella pneumoniae abundance and pH levels, the preliminary results indicated context-dependent effects of fiber fermentation on Klebsiella pneumoniae suppression. This highlighted the detailed interaction between fiber, microbial communities, and environmental factors.
The Context-dependent Effects of Fiber Fermentaon on Klebsiella Pneumonia Suppression
The gut-microbiome is a crucial part of the human digestive system, responsible for the regulation of metabolism as well as the immune system. Fiber and high fiber diets have been researched to understand their correlation with the health of the gut-microbiome. However, recent findings have shown that fiber can have additional health effects, such as inflammation, in certain populations (Wastyk et al., 2021). This unexpected result may stem from variations in individual microbiomes, influencing its interactions with dietary fibers and its resulting gut composition.
The Raman lab investigates creating diverse microbial communities in different metabolic backgrounds to define functional relationships. Their model focuses on engineered bacterial communities targeting the anbiotic-resistant pathogen, Klebsiella pneumoniae (Oliveira et al., 2024). I am working to investigate a small part of this process, specifically how dietary fiber influences microbial community function, hypothesizing that fiber fermentation varies based on metabolic background.
In the experiment, Klebsiella pneumoniae is cultured in five unique commensal gut strains, with several media conditions supplemented with various fibers. In reviewing the Klebsiella pneumoniae abundance and pH levels, the preliminary results indicated context-dependent effects of fiber fermentation on Klebsiella pneumoniae suppression. This highlighted the detailed interaction between fiber, microbial communities, and environmental factors.