Design, Synthesis, and Evaluation of Carboxylic Compounds for Antileishmanial Activity
Session Number
2
Advisor(s)
Dr. John Thurmond, IMSA
Location
A155
Discipline
Chemistry
Start Date
15-4-2026 11:10 AM
End Date
15-4-2026 11:55 AM
Abstract
Leishmaniasis is a neglected tropical disease that is estimated to affect more than 1.6 million people annually. This disease particularly ravages developing regions with limited access to healthcare. Current treatments against this tropical disease result in devastating side effects on patients, including organ toxicity and prolonged hospitalization. They are often limited by poor pharmacokinetic profiles that cannot maintain efficacious antigen concentrations. The purpose of this study is to synthesize preferred compounds for treating leishmaniasis without the adverse side effects of current remedies. Current research indicates that certain carboxylic acid groups exhibit antileishmanial activity. This study examines a series of carboxylic acids subjected to column chromatography, workups, and thin-layer chromatography plate analysis. Further results on the compounds will be presented after the carboxylic acid groups are characterized by infrared spectroscopy.
Design, Synthesis, and Evaluation of Carboxylic Compounds for Antileishmanial Activity
A155
Leishmaniasis is a neglected tropical disease that is estimated to affect more than 1.6 million people annually. This disease particularly ravages developing regions with limited access to healthcare. Current treatments against this tropical disease result in devastating side effects on patients, including organ toxicity and prolonged hospitalization. They are often limited by poor pharmacokinetic profiles that cannot maintain efficacious antigen concentrations. The purpose of this study is to synthesize preferred compounds for treating leishmaniasis without the adverse side effects of current remedies. Current research indicates that certain carboxylic acid groups exhibit antileishmanial activity. This study examines a series of carboxylic acids subjected to column chromatography, workups, and thin-layer chromatography plate analysis. Further results on the compounds will be presented after the carboxylic acid groups are characterized by infrared spectroscopy.