Effect of Somatic Growth of Pulmonary Artery and Inferior Vena Cava on Fontan Conduit
Session Number
MEDH 26
Advisor(s)
Dr. Narutoshi Hibino MD, PhD., University of Chicago, Hibino Lab
Discipline
Medical and Health Sciences
Start Date
17-4-2024 10:45 AM
End Date
17-4-2024 11:00 AM
Abstract
Single ventricular defects are a type of congenital heart disease that can be treated through the Fontan Procedure, where a conduit is implanted connecting the inferior vena cava (IVC) to the pulmonary artery (PA). Native vasculature grows over time, whereas the synthetic conduit does not. This study focused on the growth of the PA over time, resulting in conduit shape and hemodynamic changes. Three patients were analyzed at two timepoints spanning a range of one and four years, all of which had 18-20 mm Fontan conduits. Each timepoint’s desired Fontan route was created into a 3D model through a process called segmentation using an MRI scan in Scan IP software. Abaqus CAE software was utilized to simulate exercise pressure conditions and investigate changes in structure. Results demonstrated that while the PA grew over time, Von Mises Stress changed and the conduit shifted. These findings explained the disproportionate movement of conduit walls as somatic PA growth occurred. Next steps include obtaining Computational Fluid Dynamics data on XFlow software for a more thorough analysis on hemodynamic state. In the future, this research can inform patient-specific conduit placement and size to achieve ideal hemodynamics, thus enhancing the Fontan Procedure to improve patient outcomes.
Effect of Somatic Growth of Pulmonary Artery and Inferior Vena Cava on Fontan Conduit
Single ventricular defects are a type of congenital heart disease that can be treated through the Fontan Procedure, where a conduit is implanted connecting the inferior vena cava (IVC) to the pulmonary artery (PA). Native vasculature grows over time, whereas the synthetic conduit does not. This study focused on the growth of the PA over time, resulting in conduit shape and hemodynamic changes. Three patients were analyzed at two timepoints spanning a range of one and four years, all of which had 18-20 mm Fontan conduits. Each timepoint’s desired Fontan route was created into a 3D model through a process called segmentation using an MRI scan in Scan IP software. Abaqus CAE software was utilized to simulate exercise pressure conditions and investigate changes in structure. Results demonstrated that while the PA grew over time, Von Mises Stress changed and the conduit shifted. These findings explained the disproportionate movement of conduit walls as somatic PA growth occurred. Next steps include obtaining Computational Fluid Dynamics data on XFlow software for a more thorough analysis on hemodynamic state. In the future, this research can inform patient-specific conduit placement and size to achieve ideal hemodynamics, thus enhancing the Fontan Procedure to improve patient outcomes.