Chemistry

We modeled the binding of a segment of gastric carcinoma to the polymer segment (2E,4R,5S)-2,3,4,5-tetrahydroxy-6-(palmitoyloxy)hex-2-enoic acid using SPARTAN Student v9. Our aim is to provide more data to the drug industry on how gastric carcinoma binds to molecular strands and, by analogy, real proteins. When producing drugs for different diseases, scientists can save time and resources using modeling software because ... Read More

Eosinophilic Esophagitis (EoE) is an autoimmune condition that causes inflammation of the digestive tract due to a high buildup of eosinophils, a white blood cell that both mediates and controls responses to allergies and asthma. When trigger allergens are exposed to EoE patients, the immune system gets activated, leading to the buildup of eosinophils contributing to tissue damage and inflammation ... Read More

A common underlying factor in many cases of eczema, atopic dermatitis, is a weakened skin barrier via damaged barrier proteins such as filaggrin which causes a greater risk for infection. While treatments including Tofacitinib have already been developed, many of them are topical steroids that do not provide permanent recovery and can trigger side effects such as skin thinning. This ... Read More

Leishmaniasis is a parasitic disease found in 88 countries, a majority of which are located in the tropic or subtropics, earning it the title of a neglected tropical disease (NTD). The disease is primarily characterized by fevers, enlarged spleens, weight loss, and swollen glands. This study was done in collaboration with the Drugs for Neglected Disease Initiative (DNDi) and the ... Read More