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Wednesday, April 19th
8:50 AM

The Binding Energies and Interactions of a Gastric Carcinoma Segment with the Polymer Segment (2E,4R,5S)-2,3,4,5-tetrahydroxy-6-(palmitoyloxy)hex-2-enoic acid Using Molecular Modeling

Meera Mutharasan '24, Illinois Mathematics and Science Academy
Kavya Reddy '24, Illinois Mathematics and Science Academy
Ashwin Nair '24, Illinois Mathematics and Science Academy

8:50 AM - 9:05 AM

We modeled the binding of a segment of gastric carcinoma to the polymer segment (2E,4R,5S)-2,3,4,5-tetrahydroxy-6-(palmitoyloxy)hex-2-enoic acid using SPARTAN Student v9. Our aim is to provide more data to the drug industry on how gastric carcinoma binds to molecular strands and, by analogy, real proteins. When producing drugs for different diseases, scientists can save time and resources using modeling software because ... Read More

9:05 AM

Applying Computer- Aided Drug Discovery Techniques For the Improvement of Proton Pump Inhibitors Used For the Treatment of Eosinophilic Esophagitis (EoE)

Komal Chivukula, Illinois Mathematics and Science Academy

9:05 AM - 9:20 AM

Eosinophilic Esophagitis (EoE) is an autoimmune condition that causes inflammation of the digestive tract due to a high buildup of eosinophils, a white blood cell that both mediates and controls responses to allergies and asthma. When trigger allergens are exposed to EoE patients, the immune system gets activated, leading to the buildup of eosinophils contributing to tissue damage and inflammation ... Read More

10:20 AM

The Effect of Janus-Kinase Inhibitors on the Neutralization of Eczema

Nathaniel Huang '24, Illinois Mathematics and Science Academy

10:20 AM - 10:35 AM

A common underlying factor in many cases of eczema, atopic dermatitis, is a weakened skin barrier via damaged barrier proteins such as filaggrin which causes a greater risk for infection. While treatments including Tofacitinib have already been developed, many of them are topical steroids that do not provide permanent recovery and can trigger side effects such as skin thinning. This ... Read More

10:50 AM

Design and Synthesis of Potential Treatments for Leishmaniasis

Jadesola Suleiman '23, Illinois Mathematics and Science Academy

10:50 AM - 11:05 AM

Leishmaniasis is a parasitic disease found in 88 countries, a majority of which are located in the tropic or subtropics, earning it the title of a neglected tropical disease (NTD). The disease is primarily characterized by fevers, enlarged spleens, weight loss, and swollen glands. This study was done in collaboration with the Drugs for Neglected Disease Initiative (DNDi) and the ... Read More

Finding an Alternative to Metformin

Dominik Kozbiel '24, Illinois Mathematics and Science Academy

10:50 AM - 11:05 AM

Metformin is one of the oldest drugs that is still currently used, and it is the most prescribed drug for treating diabetes. While Metformin is incredibly inert (as a result of it being a biguanide), it does not bind to its binding site too strongly. Through my research, I have developed hundreds of alternatives to Metformin using computer aided drug ... Read More

Potential Treatments for Mycetoma Using Synthesized Ferinamol Derivatives

Ireland Morgan '23, Illinois Mathematics and Science Academy
Damilola Tabiti '23, Illinois Mathematics and Science Academy

10:50 AM - 11:05 AM

Eumycetoma, or fungal infections of mycetoma, plague third world countries. The symptoms of this disease include lesions with fistulae and abscesses filled with pus on the limbs, which sometimes need amputation. The current treatment methods of antifungal antibiotics and antifungal therapy of eumycetoma are currently not very effective. This project’s intention is to synthesize derivatives of Fenarimol, an antifungal agent, ... Read More