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Wednesday, April 17th
8:15 AM

DDX18 Plays a Functional Role in the Association of Centromeres and Heterochromatin to the Nucleolus

Cara Jacob '24, Illinois Mathematics and Science Academy
Josie Kim '25, Illinois Mathematics and Science Academy
Vignesh Tiruvannamalai '24, Illinois Mathematics and Science Academy

8:15 AM - 8:30 AM

Centromeres and heterochromatin play significant roles in gene expression regulation. We hypothesize that DDX18, a protein that localizes in the nucleolus, may play a role anchoring centromeres to the nucleolus and organizing perinucleolar heterochromatin. Investigating its role in these processes would allow us to better understand the mechanism and purpose behind the centromere-nucleolus and heterochromatin-nucleolar associations, and broader implications for ... Read More

Developing a Questionnaire to Measure the Efficacy of a Multiomic Detection Model for Colorectal Cancer Screening

Ava Gonzalez '24, Illinois Mathematics and Science Acaademy
Ashwin Nair '24, Illinois Mathematics and Science Academy

8:15 AM - 8:30 AM

The U.S. Preventive Services Task Force (USPSTF) states that adults aged 45 to 75 not at increased risk for colorectal cancer (CRC) should be screened once every ten years. Literature shows three out of ten adults don’t adhere to CRC screening guidelines due to socioeconomic status, fear of screening methods, affordability, and other inhibitors. Insufficient information is available on improving ... Read More

Development of a Human-Mouse Chimera to Study the Toxic Effects of HIV Antiretroviral Drugs

Aahana Das '25, Illinois Mathematics and Science Academy

8:15 AM - 8:30 AM

The course of treatments for HIV has been revolutionized by the development of antiretroviral drugs. However, in many instances, these drugs induce toxicity via mitochondrial dysfunction and the release of neurotoxins, and long-term toxicity remains an area of worry for people living with HIV. Our objective is to develop a humanized mouse model to study the toxic effects of HIV ... Read More

Drug Discovery on Tropical Disease

Aditya Kumar '25, Illinois Mathematics and Science Academy

8:15 AM - 8:30 AM

Leishmaniasis, a tropical disease, poses significant challenges due to the unreliability, toxicity, and cost of current treatments. Addressing this, a novel treatment approach is under investigation, focusing on 5-chloro-1,3-benzoxazol-2-amine, a promising compound identified through the Drugs for Neglected Diseases Initiative's Open Synthesis Network. This molecule is undergoing rigorous testing, including Proton Nuclear Magnetic Resonance and Infrared Spectroscopy, to verify its ... Read More

8:35 AM

5-hydroxymethylcytosine and TET Enzymes in Neuroblastoma

EmmaLi Isham, Illinois Mathematics and Science Academy

8:35 AM - 8:50 AM

One of the hallmarks of aggressive neuroblastoma is amplification of the MYCN oncogene which defines groups of patients with poor prognosis. The Applebaum Lab has shown that in MYCN-amplified neuroblastoma, 5-hmC (a DNA modification of open chromatin placed by the Ten-Eleven Translocation (TET) proteins) and H3K27me3, a marker of closed chromatin, co-localize. This co-localization results in the repression of genes ... Read More

Monobenzone Nanoparticles for the Treatment of Melanoma Tumor Cells

Jongwoo Kim '25, Illinois Mathematics and Science Academy

8:35 AM - 8:50 AM

Melanoma is a highly malignant form of skin cancer originating from melanocytes, cells responsible for pigment production, and there exist limited treatments for the disease. Monobenzyl ether of hydroquinone (MBEH), approved as a treatment for Vitiligo, targets the melanogenic pathway of melanin synthesis through its conversion into a toxic product by tyrosinase. Due to its toxicity at concentrations to get ... Read More

The Role of the Protein Tyrosine Phosphatase SHP-1 in TRPV1-mediated Pain Behavior

Kaylee Hwang '25, Illinois Mathematics and Science Academy

8:35 AM - 8:50 AM

The capsaicin receptor TRPV1 is expressed in pain-sensing neurons and has been an attractive drug target for pain control. However, its physiological function such as regulating normal body temperature and heat sensation made TRPV1-targeting drug development challenging. Previous studies showed that the protein tyrosine phosphatase enzyme SHP-1 can modulate TRPV1 in the dorsal root ganglion (DRG). Our aim was to ... Read More

8:55 AM

Electron Paramagnetic Resonance Nanoradicals for Quantitative Intracellular Tumor Oximetric Images

Justina Kostiv '24, Illinois Mathematics and Science Academy

8:55 AM - 9:10 AM

In large solid tumors, a hypoxic core often indicates malignant progression, metastasis, and reduced responsiveness to chemotherapy and radiation. Personalized treatments can benefit from precise measurements of tumor oxygenation and reoxygenation of the tumor. Electron Paramagnetic Resonance Imaging (EPRI) along with an oxygen-measuring paramagnetic probe were used to assess tumor oxygenation in vivo. Triarylmethyl (trityl) radical has been known for ... Read More

Evaluation of Y2O3:Eu@SiO2 Nanoparticles as Photosensitizer for X- Ray Activated Photodynamic Therapy in Cancer

Divya Brahmbhatt '24, Illinois Mathematics and Science Academy

8:55 AM - 9:10 AM

We are developing an innovative nanoparticle-based photosensitizer aimed at enhancing photodynamic therapy (PDT) for cancer, addressing key challenges such as low light penetration and oxygen deficit in tumors. We synthesized a new photosensitizer, Y2O3:Eu@SiO2, featuring a europium-doped yttrium oxide core within a silica shell, and assessed its properties and functionality through transmission electron microscopy (TEM) and dihydroethidium (DHE) assays. Our ... Read More

Impact of Malate Dehydrogenase 2 Skin Epithelial Knockout on Basal Keratinocyte Proliferation

Anisha Kolambe '24, Illinois Mathematics and Science Academy

8:55 AM - 9:10 AM

As a barrier to the external environment, the skin serves as the body’s primary mechanism for physical and chemical defense, thermoregulation, and fluid retention. In both tissue homeostasis and wound repair, layers of skin form as cells migrate upward following proliferation and differentiation in the basal layer. Metabolism maintains physiological activity, with inhibited function in diseases such as diabetes leading ... Read More

Investigating the Effects of Light Exposure During Sleep and Circadian Rhythm in Adolescents and Young Adults

Andrew Wong '25, Illinois Mathematics and Science Academy

8:55 AM - 9:10 AM

This research investigates the impact of light on sleep and circadian rhythm in adolescents and young adults. Light serves as a primary regulator of circadian rhythms, influencing sleep-wake cycles and overall health. By synthesizing findings from various studies, we explore the effects of light intensity, duration, and wavelength on sleep patterns and circadian timing. Studies demonstrate a gradual shift towards ... Read More

Temporal Aspects of Novel Thioredoxin Glutathione Reductase Inhibitors

Joseph Paras '24, Illinois Mathematics and Science Academy

8:55 AM - 9:10 AM

Despite being one of the most influential parasitic diseases in developing countries, schistosomiasis has historically been treated as an orphan disease. To date, one drug, praziquantel, exists for its treatment. However, praziquantel sees faults in its effects on juvenile worms and has been proven to be susceptible to developed resistance in schistosomes. Most current developments towards new treatment for schistosomiasis ... Read More

9:20 AM

Assessing the Impact of Glasgow Coma Scale (GCS) Score Transitions in the First 24 Hours on Clinical Outcomes in Patients with Traumatic Brain Injury (TBI)

Haley Shah '25, Illinois Mathematics and Science Academy

9:20 AM - 9:35 AM

Traumatic Brain Injuries (TBI) pose a substantial global health threat, representing a significant contributor to mortality rates worldwide. TBI is brain damage caused by external force, with varying severity from mild to severe, which can be classified using the Glasgow Coma Scale (GCS). This study aims to investigate the impact of GCS score transitions of penetrating and severe TBI patients ... Read More

Visual Tests as a Proxy for Top-Down Processing Evaluations in Cochlear Implant Patients

Kannan Ilamparithi '25, Illinois Mathematics and Science Academy

9:20 AM - 9:35 AM

Cochlear implants have benefited hearing-impaired patients by providing a medium through which they can perceive sound. However postoperative dissatisfaction remains an issue amongst a significant proportion of patients. Studies suggest that patient dissatisfaction may be attributable to a lower top-down processing ability amongst certain patients with cochlear implants. However testing their processing ability is difficult considering that patients with cochlear ... Read More

9:40 AM

Classifying Admission Characteristics of TBI Patients Using K-means Clustering

Rithik Thekiniath '24, Illinois Mathematics and Science Academy

9:40 AM - 9:55 AM

Traumatic Brain Injury (TBI) remains a significant health concern that often results in long-term cognitive impairments, coma, or even mortality. Current classification methods are primarily reliant on the Glasgow Coma Scale (GCS) and face limitations in representing the complexity and variability of TBIs. This study utilizes unsupervised learning through a k-means algorithm to cluster TBI patients at Beth Israel Deaconess ... Read More

Effect of a Coupled Hypoxia and Exercise Treatment on Neuropathic Pain in Female Rats with Chronic Spinal Cord Injury

Dashiell Leigh '24, Illinois Mathematics and Science Academy

9:40 AM - 9:55 AM

Spinal Cord Injury (SCI), an interruption of spinal axons, impacts millions of people, and can lead to quadriplegia and damage to essential respiratory pathways. To date, it is medically irreversible. Recent animal studies suggest that Intermittent Hypoxia (IH) and exercise training are effective treatments. IH, or exposure to low oxygen levels, has been shown to trigger phrenic long term facilitation ... Read More

Metformin Analogs for Diabetes Treatment

Iris Amit '24, Illinois Mathematics and Science Academy
Sriya Mudumba '24, Illinois Mathematics and Science Academy

9:40 AM - 9:55 AM

Metformin is used to treat Diabetes, a disease that plagues people worldwide. Metformin binds to the MF8 ligand, and strengthening that binding affinity indicates that there is less need for more doses of the medication. Computational drug design was used due to its cost- effectiveness and ability to display certain molecules while also saving time for researchers. Utilizing the SeeSAR ... Read More

Quantification of Cells with Modifications Relating to the RB1 Pathway

Jeanmyung Yu '25, Illinois Mathematics and Science Academy

9:40 AM - 9:55 AM

The retinoblastoma tumor suppressor (RB1) is a vital tumor suppressor gene. It prevents the cell from transitioning to the S phase from G phase by inhibiting E2F activity which limits cell proliferation and facilitates a stable exit from the cell cycle. Inactivation of RB1 thus allows for the expression of genes necessary for the cell cycle to progress and results ... Read More

10:00 AM

A Novel Treatment for Triple-negative Breast Cancer: NS1643

Jaden Blankenship '25, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Triple Negative Breast Cancer (TNBC) remains a significant cause of mortality, with 150,000 deaths annually worldwide. To address this staggering statistic, a comprehensive literature review was undertaken to explore TNBC treatments, revealing phosphorylated caveolin-1 (Cav-1) expression as pivotal in breast cancer metastasis. Interestingly, human triple-negative breast cancer cells (MDA- 231) uniquely overexpress the K+ channel Kv11.1, providing a potential drug ... Read More

Epidemiological Trends of SARS-CoV-2 Infections during Pregnancy in Chicago

Kavya Reddy '24, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

The COVID-19 pandemic has affected many individuals and the epidemiology of SARS-CoV-2 infections has varied significantly across age groups. Pregnant people were especially vulnerable and at higher risk of more severe infections. We investigated epidemiologic trends of SARS-CoV-2 cases in pregnant people compared to trends in children and adults in Chicago. We identified positive SARS-CoV-2 pregnancies (March 2020-November 2022) at ... Read More

Genetic Modification of Adenovirus Vectors for Bone Cancer Treatment

Cindy Xu '25, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Adenoviruses are frequently employed in clinical studies for oncolytic virotherapy and gene therapy, as well as for delivering genes to different cell types. The adenovirus family consists of non-enveloped DNA viruses with a linear genome of 30–38 kb. The use of human serotype 5 of species C adenovirus vectors is advantageous for delivering genes into a variety of dividing and ... Read More

Local Availability of Medications for Opiate Use Disorder Across Chicago

Diya Kamath '24, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

The main public health initiatives to address the pandemic of lethal opiate overdoses have been to increase availability of medications for opioid use disorder (MOUD). Despite expanded access, studies have demonstrated the existence of community-level barriers. To date, none have looked at MOUD availability in Chicago. In this project, we analyzed the availability of suboxone films, Narcan/naloxone, and naloxone standing ... Read More

Machine Learning to Predict Next-day Dialysis in Critically Ill Patients

Manhitha Mamillapalli '25, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Background: Some patients in the intensive care unit (ICU) experience acute kidney injury (AKI) or other conditions requiring dialysis as a treatment to support failing kidneys. Machine learning on electronic health record (EHR) data holds promise for tasks such as helping clinical teams with planning and for prognostic purposes.

Methods: Here we investigate the likelihood of a patient’s next-day dialysis ... Read More

Optimizing Memory via Real-time Monitoring of Neural Data with Adaptive Brain Stimulation Machine Learning Algorithms

Ryan Cho '25, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Aging and neurological disorders lead to neurodegeneration that decreases memory function. Deep brain stimulation (DBS) has emerged as a potential solution by stimulating neurons with electricity to enhance neuronal activity during memory tasks. This study hypothesizes that DBS improves memory when targeted towards deficient memory encoding states due to state-dependent effects by influencing brain networks related to semantic organization. This ... Read More

Synthesis of Benzoxazole-based Compounds for Leishmaniasis

Mesoma Akpuokwe '24, Illinois Mathematics and Science Academy
Kosi Okeke '24, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Leishmaniasis is a disease caused by parasites of the Leishmania genus. The disease is prevalent in tropical and subtropical regions, such as parts of Asia, Africa, the Middle East, and Latin America. Leishmaniasis is caused by the bite of infected sandflies, which transmit the parasites during their blood-feeding process. It starts out with an infected sandfly biting a mammalian host, ... Read More

The Effect of Environmental Toxins on Motor Behavior of Caenorhabditis Elegans

Manasa Balasubramanian '24, Illinois Mathematics and Science Academy
Johanna Germo '24, Illinois Mathematics and Science Academy
Brent Rodrigo '25, Illinois Mathematics and Science Academy
Annabelle Zhang '24, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Amyotrophic lateral sclerosis (ALS) is a rare degenerative neuromuscular disease that affects motor neurons in the brain and spinal cord. Several recent studies have focused on a link between ALS and exposure to environmental toxins such as microplastics and herbicides. To simulate the potential effects of microplastics on a functioning nervous system, we introduced Caenorhabditis elegans (C. elegans) to the ... Read More

The Effects of XBP1 Agonist IXA4 on Hepatic and Serum Bile Acid Levels of FXRKO vs. C57BL/6 Mice

Neev Patel '25, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Bile is essential to digestion because it solubilizes fats for absorption in the intestine. The rate-limiting step in bile acid synthesis is the addition of hydroxyl at the C-7 position of cholesterol by the hepatic enzyme Cholesterol 7-alpha hydroxylase (CYP7A1). The gene CYP7A1 is regulated by the Farnesoid X Receptor (FXR), which activates the Small Heterodimer Partner (SHP) suppressing CYP7A1. ... Read More

Topic Modelling Approaches for Identification of Topics within Clinical Notes of Emergency Department Patients with Opioid Misuse

Madhav Hota '24, Illinois Mathematics and Science Academy

10:00 AM - 10:15 AM

Opioid misuse is a significant public health challenge in the US, with escalating impacts on emergency medical services and emergency departments. Patients with opioid misuse are often treated as a homogenous population when there are likely subgroups that may influence optimal clinical care. This study aims to investigate and identify these latent groups among patients with opioid misuse. A sample ... Read More

10:25 AM

Bi-phasic Regulation of miR-17~92 in Pulmonary Arterial Smooth Muscle Cells (PASMC)

Arjun Cherukuri '24

10:25 AM - 10:40 AM

We have reported previously that during hypoxia exposure, the expression of mature miR- 17~92 was first upregulated and then downregulated in PASMC and in mouse lungs in vitro and in vivo. Here we investigated the mechanisms regulating this bi-phasic expression of miR-17~92 in PASMC in hypoxia. We measured the level of primary miR-17~92 in PASMC during hypoxia exposure and found ... Read More

DNDi OSN “Hit to Lead” Potential Therapies for Leishmaniasis

Gabi Pride '24, Illinois Math and Science Academy
Trinh Yong '25, Illinois Mathematics and Science Academy

10:25 AM - 10:40 AM

Leishmaniasis is an infectious, neglected tropical disease that needs further funding for research purposes. Leishmaniasis is a parasite associated with neglected populations who experience poor domestic sanitary conditions, weak immune systems, malnutrition, and lack of financial resources. In majority of cases, this disease is fatal if left untreated. Treatments and therapies have shown a lack of effectiveness over the disease ... Read More

Experimental Paradigm for Studying Impairments in Bilateral Reaching and Grasping After Stroke

JaeJun Park '24, Illinois Mathematics and Science Academy

10:25 AM - 10:40 AM

After stroke, patients experience significant loss in performing activities of daily living (ADL) such as reach-and-grasp. The paresis mainly affects the side of the body contralateral to the lesion and slight deficits to the ipsilesional side, causing an asymmetry in impairment. However, we lack a comprehensive understanding of how functional reach-to-grasp is impaired following stroke, especially during bi-manual tasks. This ... Read More

Exploring the Impact of Ceramide Synthesis Enzymes on Atopic Dermatitis Severity

Mikaella Moraga '25, Illinois Mathematics and Science Academy

10:25 AM - 10:40 AM

Atopic dermatitis (AD; eczema) is a chronic skin disorder characterized by inflammation, itching, and compromised skin barrier function. Pathogenesis involves genetic factors, immune dysregulation, and skin barrier ceramide alterations. This research project explores the relationship between the ceramide de novo pathway and AD severity. Severity was determined serially based on assessing erythema, scaling, edema, and erosion using a 12-point scale ... Read More

Measuring the Vital Function of the Skin Barrier

Sindhu Chalasani '24, Illinois Mathematics and Science Academy
Aaron Bernstein

10:25 AM - 10:40 AM

The epidermal compartment of skin balances proliferation for tissue self-renewal and terminal differentiation for essential barrier function. This study examines how keratinocytes, the cells that comprise the epidermis, build a barrier as they become terminally differentiated. To assess the function of the epidermal barrier, we used an epithelial voltohmmeter (EVOM2) to measure the transepithelial electrical resistance (TEER, Ω⋅cm2) of keratinocyte ... Read More

Meta-Analysis Research to Discover Novel Method for Increasing the Role of NK Cells in LAG-3 Immunotherapy to Increase Efficiency of Melanoma Treatment

Anirudh Saravanan, RISE Program

10:25 AM - 10:40 AM

The purpose of this meta-analysis was to determine the efficiency and stability of introducing natural killer (NK) cells in the existing immunotherapy for melanoma cancer known as LAG-3 CD223. NK cells are already in use for HIV immunotherapy, however, are not available in current cancer treatments. Including NK cells can allow the body to develop a natural means to attack ... Read More

Synthesis of the Nanoscintilators and Characterization of the NanoparticlesInvolved in X-Ray Activated Therapy for Cancer Research

Jediael Chintha '25, Illinois Mathematics and Science Academy

10:25 AM - 10:40 AM

In cancer treatment, nano-scintillators have emerged as crucial for advancing X-ray-activated therapy. These innovative materials possess a unique ability to convert X-ray radiation into visible light, enhancing the effectiveness of treatment and reducing damage to healthy tissues. This paper provides an in-depth exploration of the synthesis and characterization of nano-scintillators designed explicitly for this purpose. It delves into various fabrication ... Read More

10:45 AM

B7-H3 Specific CAR T-Cell Three-Dimensional Killing Assay on Synovial Sarcoma Cell Lines

Ayesha Bobat '25, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

The Pollack Lab focuses on treating sarcoma tumors by performing in-vitro two-dimensional and three-dimensional killing assays with chimeric antigen receptor (CAR) T-cell therapy, a form of immunotherapy. Specifically, CAR T-cells are made by isolating T-cells from a patient’s blood and genetically modifying them to specifically target the human B7-H3 gene on the surface of a tumor. B7-H3 is a tumor ... Read More

Characterizing Neonatal Human Epidermal Keratinocytes-derived Exosomes

Devarsh Shah '25, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Painful diabetic neuropathy (PDN) is a debilitating complication of diabetes with patients suffering from a painful, burning sensation in their extremities. Available treatments have limited effect in masking the pain without addressing the underlying mechanisms of the disease, which are currently poorly understood. Keratinocytes are in close proximity to cutaneous nerve terminals, enabling bidirectional communication between keratinocytes and cutaneous nerves. ... Read More

Design of Novel Ribociclib Derivatives Using Computational Analysis as Potential Therapeutics for Breast Cancer

Abigail Botello '24, Illinois Mathematics and Science Academy
Karla Sanchez '24, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Approximately 10% of breast cancers are hormone-receptor-positive. Despite the array of available drugs for metastatic breast cancer, ribociclib stands out as one of the most potent options, particularly effective against HER2- breast cancer. However, its efficacy is countered by notable side effects including liver issues, neutropenia, skin reactions, and cardiac/respiratory problems. This research project aimed to computationally design molecules derived ... Read More

Effect of Somatic Growth of Pulmonary Artery and Inferior Vena Cava on Fontan Conduit

Aashi Dharia '25, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Single ventricular defects are a type of congenital heart disease that can be treated through the Fontan Procedure, where a conduit is implanted connecting the inferior vena cava (IVC) to the pulmonary artery (PA). Native vasculature grows over time, whereas the synthetic conduit does not. This study focused on the growth of the PA over time, resulting in conduit shape ... Read More

Inducing Physical Changes of Cancer Cells By Facilitating K+ Efflux of Big Potassium (BK) Channels; New Potential Target Genes in Cancer Metastasi Research

Yanel Gonzalez '24, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Changes in the physical characteristics of cancer cells are a hallmark of tumorigenesis, and understanding how these changes affect tumor progression can provide novel therapeutic insights. Prior studies have discovered that increasing cancer cell stiffness reduces metastatic burden by activating cytotoxic T lymphocytes. MRTFA and MRTFB are two transcription factors that cause the stiffening of cancer cells, and preliminary data ... Read More

Measuring Proliferation of Keratinocyte Skin Cells

Anjali Ali '25, Illinois Mathematics and Science Academy
Sarah Kumar '25, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Skin is a vital organ that protects us from harmful substances including chemicals and bacteria. The epidermis, the outermost layer of skin, is in equilibrium between proliferation and differentiation to maintain tissue regeneration and barrier function, respectively. This equilibrium is largely dictated by calcium levels. Our study aims to understand the proliferation of keratinocyte skin cells in response to different ... Read More

Novel Convolutional Neural Networks for Improved Accuracy in User-accessible Brain Tumor Detection

Kevin Tian, IMSA RISE

10:45 AM - 11:00 AM

The purpose of this design investigation was to create three user-friendly artificial intelligence (AI) models, specifically convolutional neural networks (CNNs), each designed using different and novel techniques for brain tumor detection from Magnetic Resonance Imaging (MRI) scans. These models aimed to assist medical professionals in overcoming inefficiencies, reducing human error, and surpassing existing models in accuracy by addressing various gaps ... Read More

The Effects of Different Prosthetic Foot and Ankle Stiffness Combinations on Transfemoral Prosthesis Users

Rachel Coutinho '25, Illinois Mathematics and Science Academy
Yoonseo Kim '25, Illinois Mathematics and Science Academy

10:45 AM - 11:00 AM

Prosthetic foot stiffness is typically prescribed based on a person's weight and activity level, which may not be optimal for a particular patient. This study investigates how different prosthetic foot stiffness levels affect foot-ankle roll-over shape. The aim is to enhance gait function and prosthetic design for transfemoral prosthesis users. The study mechanically characterized the keel and bumper components on ... Read More

11:05 AM

Comparative Analysis of Heart Procurement Methods in Donors After Circulatory Death

Sukanya Ghosh '24, Illinois Mathematics and Science Academy

11:05 AM - 11:20 AM

Since 2019, there has been a notable rise in yearly heart transplantation rates following circulatory death (DCD) in the United States. The primary procurement methods are direct procurement and perfusion (DPP) and normothermic regional perfusion (NRP). DPP relies on ex situ machine perfusion with cold crystalloid cardioplegia followed by normothermic blood reperfusion. NRP involves in situ reperfusion using an open ... Read More

Examining the Associations of Breast Cancer Outcomes and Air Pollution in Chicago

Elaine Elaine Rao '25, Illinois Mathematics and Science Academy

11:05 AM - 11:20 AM

Breast cancer is a significant public health concern, with varying incidence and mortality rates among different demographic groups. Recent studies suggest a potential association between air pollution and breast cancer rates, prompting our investigation within specific Chicago areas from 2015 to 2021. Analyzing data from Metopio, across 77 community areas, we focused on PM2.5 as the primary air pollution variable. ... Read More

Improving Clinical Accuracy and False Alarm Sensitivity of Tonic-Clonic Seizure Predictors

Rhea Shah '25, Illinois Mathematics and Science Academy

11:05 AM - 11:20 AM

Machine learning applications in diagnosing and predicting seizure symptoms among high-risk patients are critical to prevent life-threatening injuries. Despite existing research achieving near-perfect accuracies in controlled environments, existing models often falter in clinical settings and wearable devices, resulting in high false alarm rates and lower prediction success for Tonic-Clonic seizures. The OpenSeizureDatabase has revolutionized training models by incorporating previously unavailable ... Read More

Neonatal Mesechenchymal Stem Cells Seeded Scaffold Support Tissue Regeneration

Brooke Hilderbrant '24, Illinois Mathematics and Science Academy
Arnav Patel '25, Illinois Mathematics and Science Academy

11:05 AM - 11:20 AM

Bladder exstrophy and neuropathic bladder are conditions that lead to dysfunctional bladder function, which congenital malformations or conditions may cause. Current surgical treatment can lead to a variety of complications, sparking a need for recreating bladder tissue to repair bladder function. During the study utilizing neonatal mesenchymal stem cells (nMSCs)-seeded elastomeric Poly(1,8-octanediol-co-citrate) (POC) scaffolds, rats underwent an approximate 50% bladder ... Read More

Synthesis of Novel Compounds for Leishmaniasis

Olivia Aguilar '25, Illinois Mathematics and Science Academy
Nelly Pinon '25, Illinois Mathematics and Science Academy
Noel Skariah '25, Illinois Mathematics and Science Academy

11:05 AM - 11:20 AM

Leishmaniasis is a neglected tropical disease (NTD) affecting over 90 countries today. Visceral Leishmaniasis, is the most serious form of Leishmaniasis. Current treatment is shown to be toxic such as Liposomal amphotericin and no vaccine or medicine prevents or reduces infection. The project is partnered with Drugs for Neglected Diseases Initiative (DNDi). The purpose of this project was to use ... Read More