Through SIR, IMSA provides a mechanism that engages students in personalized learning to pursue solutions to problems and issues that challenge our global community. Partnerships with distinguished professionals at colleges and universities, research institutions, businesses, and museums allow our students to gain experience in real-world problem solving, collaboration, and scholarship. The ability to work with professionals is life-changing for our students. Many of our students have already, in high school, published and presented at local, national, and international venues. Evidence of our students’ excellence, in all fields, can be found here. These students exemplify a tradition of excellence. We set high expectations for our students, and you will find that IMSA students far exceed these expectations for accomplishments and contributions to society. They are well-prepared to solve the challenges that we will face in the future.
"Research is formalized curiosity. It is poking and prying with a purpose."- Zora Neale Hurston, in Dust Tracks on a Road, 1942
Submissions from 2022
Ancestral sequence reconstruction to improve thermostability of Rubisco Activase from maize, Sarah C. Stainbrook, Taylor Baugh '23, Naveena Mutharasan '22, Angela Ahrendt, and Joseph Jez
An Evaluation of Variant Annotation Tools – Alamut Batch, ENSEMBL Variant Effect Predictor (VEP), and ANNOVAR – for Clinical Next Generation Sequencing (NGS) based Genetic Testing, Sachleen Tuteja '23
Fragment-based drug discovery and synthesis of SARS-CoV-2 therapeutics, Hannah Johnson '22
JAG1 Role in the Extravasation of Metastasized TNBC Tumor Cells, Bhavya Vegesna '23
On the relationship between pain variability and relief in randomized clinical trials, Siddharth Tiwari '22, Andrew D. Vigotshy, and Apkar V. Apkarian
Status of Vitamin D in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS), Gabriel Delgado '22
The Impact of CPSF6 on the Innate Immune Response to HIV Infection, Kenith Taukolo '23
Using Machine Learning to Recognize Chronic Rhinosinusitis, Irene Liu '23
Submissions from 2021
A machine learning approach to the detection of ghosting and scattered light artifacts in dark energy survey images, C. Chang, A. Drlica-Wagner, S. M. Kent, B. Nord, D. M. Wang, and M.H.L.S. Wang
Computational Prediction of Mutagenesis in Glycine max Rubisco Activase Monomer for Increased Thermal Stability, Catherine B. Emanuel, Hamza Haq '21, Vasanth Ramesh '21, Jaden Wang '21, Angela Ahrendt, and Sarah Stainbrook
Crystal structure of (E)-doxepin hydrochloride, C19H22NOCl, Jerry Hong '20, Joseph T. Golab, James A. Kaduk, Amy M. Gindhart, and Thomas N. Blanton
Crystal structure of pimecrolimus Form B, C43H68ClNO11, Shivang Bhaskar '20, Joseph T. Golab, James A. Kaduk, Amy M. Gindhart, and Thomas N. Blanton
EutroPod, Siddharth Tiwari '22, Jasmine Liu '22, Rishitha Boddu '22, and Philip Yi '22
Exploring Competing Perspectives on How to Design Open Innovation Program for High School STEM Education: A Case Study, Sam Youl Lee and Minseo Jung '22
Fragment-Based Drug Discovery of SARS-CoV-2 Therapeutics, Hannah Johnson '22
On the relationship between pain variability and relief in randomized clinical trials, Siddharth Tiwari '22
On the relationship between pain variability and relief in randomized clinical trials, Siddharth Tiwari '22
Searching for a New Open Innovation Education for Generation Z, Minseo "Emily" Jung '22, Kaylee Zhou '22, Nadia Ludwig '22, and Rishik Ummareddy '22
The Emergence of Social Innovation from Youth Innovation Club and Civic Organizations, Minseo "Emily" Jung '22
The Enigma of Clinical Next Generation Sequencing (NGS) based Genetic Testing Variant Annotation Tools: A Performance Evaluation Study, Sachleen Tuteja '23
The Enigma of Clinical Next Generation Sequencing (NGS) based Genetic Testing Variant Annotation Tools: A Performance Evaluation Study, Sachleen Tuteja '23
What is the numerical nature of pain relief?, Andrew D. Vigotsky, Siddharth Tiwari '22, James W. Griffith, and A. V. Apkarian
Submissions from 2020
Auschwitz, Sophia Pribus '20
Code vestimentaire, Elizaveta Kuzmina '20
Crystal structure of ipratropium bromide monohydrate, C20H30NO3Br(H2O), Shivang Bhaskar '20, Joseph T. Golab, James A. Kaduk, Amy M. Gindhart, and Thomas N. Blanton
Crystal structure of pantoprazole sodium sesquihydrate Form I, C16H14F2N3O4SNa(H2O)1.5, Diana Gonzalez '20, Joseph T. Golab, James A. Kaduk, Amy M. Gindhart, and Thomas N. Blanton
Crystal structures of two isostructural compounds: a second polymorph of dipotassium hydrogen citrate, K2HC6H5O7, and potassium rubidium hydrogen citrate, KRbHC6H5O7, Diana Gonzalez '20, Joseph T. Golab, Andrew J. Cigler, and James A. Kaduk
D'accord, débarrassez votre bureau, Brenna Christoffel '21
Désiderium, Nikita Elkin '20
Development of Double-Controlled Drug Eluting Stents with Nanotechnology, Brandon Park '21
Diammonium potassium citrate, (NH4)2KC6H5O7, Nilan V. Patel, Joseph T. Golab, and James A. Kaduk
Générations après, Ashley Koca '21
Immediate Early Gene Expression in D1-SPNs and D2-SPNs During a Striatum-dependent Reinforcement Learning Task, Cindy Mu '21 and Emily Shao '21
Le blanc, Ellyn Hu '21
Le conflit jusqu'à 1945, Sreyansh Mamidi '21
Machine learning prediction of glioblastoma patient one-year survival, Andrew Du '20, Warren McGee, and Jane Y. Wu
Part pour la guerre. Se battre pour ce qu'il aime. Un homme revient?, Karina Pulido '20
Powder X-ray diffraction of flucytosine, C4H4FN3O, Nilan V. Patel, Joseph T. Golab, James A. Kaduk, Amy M. Gindhart, and Thomas N. Blanton
Powder X-ray diffraction of fluorometholone, C22H29FO4, Diana Gonzalez '20, Joseph T. Golab, James A. Kaduk, Amy M. Gindhart, and Thomas N. Blanton
Powder X-ray diffraction of trimethoprim Form I, C14H18N4O3, Jerry Hong '20, Joseph T. Golab, James A. Kaduk, Amy M. Gindhart, and Thomas N. Blanton
Searching for Next Frontier Business Models: The New Perspective of Open Innovation by Generation Z, Minseo "Emily" Jung '22, Kaylee Zhou '22, Nadia Ludwig '22, and Rishik Ummareddy '22
Smart Platform Evolution for Sustainable Open Innovation: Implications for STEM Youth Programs, Minseo "Emily" Jung '22
Striatal Projection of dSPNs to GPe Pathway and Intrapallidal Projection in Relation to Parkinson’s Disease, Vasu Chalasani '20
Structures of disodium hydrogen citrate monohydrate, Na2HC6H5O7(H2O), and diammonium sodium citrate, (NH4)2NaC6H5O7, from powder diffraction data, Jerry Hong '20, Shivang Bhaskar, Joseph T. Golab, and James A. Kaduk
The Effects of Genetic and Pharmacologic Loss of the Notch4 Protein on Angiogenesis, Krishna Thakkar '20, L. A. Naiche, Victor Lin, and Jan K. Kitajewski
The Expression of ERE and NFkB & The Characterization of Stem Cell Properties in ER+ Breast Cancer Cell Lines, Utsa Bhattacharyya '21
Untitled, Neha Maddali '20
X-ray fluorescence microscopy: A method of measuring ion concentrations in the ear, Eileen Y. Brister, Zahra Vasi '20, Olga Antipova, Alan Robinson Alan Robinson, Xiaodong Tan, Aditi Agarwal, Stuart R. Stock, Alessandra Carriero, and Claus-Peter Richter
Year of Inquiry into Student Mental Health, José M. Torres, Amber Stitziel Pareja, Katie Berger, Monika Narain '21, and Ray Shang '20
Submissions from 2019
Antibacterial Activities of Extracts from Hypoxis hemerocallidea corm, Eliza Apavaloaiei '20 and Rachel Mason '20
Classifying Fiction and Non-Fiction Works Using Machine Learning, Rachna Gupta '21
Classifying Variable Stars with Gaia Color-Magnitude Diagrams, Xander Hall '20, Adam A. Miller, Nicholas Easton, and Aaron M. Geller
Comparing efficiency of water cleaning methods, Rachna Gupta '21 and Ellyn Hu '21
Computer-aided drug design for the potential treatment against Mycobacterium Tuberculosis, Alyssa Daniels '20 and Rebecca Ellington '19
Design of EFGR kinase domain inhibitors for the potential treatment of lung and other cancers, Jodie Meng '20
Diagnostic AβO-targeted probes for Alzheimer’s Disease, Nafay Abdul '20 and Sophia Pribus '20
Discovery of an EGFR Inhibitor For the Treatment of Lung and Other Cancers, Jodie Meng '20
Exploration of the Auditory System and the Prevention of Hearing Loss from Chemotherapy, Zahra Vasi '20
Les quatre indices de 1940, Sophia Pribus '20
Mariage arrangé, Madison Mazzorana '19
Ode à lâme, Grant Dexter '19
Pathogenic Resistance in Soil Microbes for Drug Discovery, Saachi Dalvi '20 and Neha Maddali '20
Risk Taking and Open Innovation: Searching for a Creative Business Model: a brief review and potential research questions for open innovation research, Minseo "Emily" Jung '22
The Influence of Fruit Juices on the Effectiveness of Amoxicillin, Krisha Patel '21 and Ruchi Patel '21
The Pathological Interaction Between Alzheimer’s Disease and Osteoporosis in 5xFAD Mouse Model, Shruti Shakthivel '20
Trébucher sur mes mots, Vincent Wang-Yan McKibben '19
Untitled, Klaybis Asllani '20
Untitled, Aabshar Ghassi '19
Untitled, Michelle Wang '20
Untitled, Mia Ye '19
Using Initial State Radiation (ISR) Jets for SUSY Search, Emily Sallenback '19 and Bert Cao '19
Submissions from 2018
A Computer-Aided Decomposition of the Complete Digraph into Orientations of K4 − e with a Double Edge, Hanson Hao '19 and Claudia Zhu '18
An Exploration of the Factors that Motivate Gifted and Talented Rural Students to Engage in STEM, Issabella Baldwin Zurek '18, Takudzwa George '18, Clinton Oshipitan '18, Robert Luo '18, and Amy Wang '18
Cell Specific Control of the Pallidostriatal Pathway, Shubha Verma '19
Classification of Intensity-Modulated Proton Therapy Plans, Louise Gabrielle Lima '19 and Alice Liu '19
Classifying Symmetric Spaces for SO(3,q), Jacob Sutter '19 and Hanson Hao '19
YES, STEM is for ALL: Diverse Perspectives on Black and Latino STEM Motivation, Adrienne Coleman; Amber Acquaye '16; Xiomara Cardona '16; Kayla Ingram '14; Trennedy Kleczewski, '16; and Elysia Sawyers '16
Submissions from 2017
Cell Memory, Katya Bezugla '18
Chromatin-modifying agents convert fibroblasts to OCT4+ and VEGFR-2+ capillary tube-forming cells, Anita Wary, Neil Wary '18, Jugajyoti Baruah, Victoria Mastej, and Kishore K. Wary
Decision making swarms, Sanza Kazadi, George Jeno '17, Xinyu Guan '17, Nick Nusgart '17, and Andriy Sheptunov '17
Designing a Low-Cost Mobile Tracking System for Communication with a Medium Earth Orbit Satellite, Peter Dong, David Beering, Harrison Carcione '18, Joseph Hutter, Gina Jiang '17, Charles Kuch '18, Soomin Park '17, Advai Podduturi '18, and Peijing Xu '18
Submissions from 2016
Molecular Mechanisms of Squamous Cell Carcinoma Tumor Stem Cell Creation via High Nitric Oxide (HNO) Adaptation, Niresh T. Kuganeswaran '16, Krishi Korrapati '17, Thomas Wan '16, Timothy Tamas, and James A. Radosevich
Npas1+ Pallidal Neurons Target Striatal Projection Neurons, Savio Chan, Kelly Glajch, Daniel Kelver, Daniel Hegeman, Qiaoling Cui, Harry Xenias, Elizabeth Augustine, Vivian Hernández, Neha Verma '17, Tina Huang, Minmin Luo, and Nicholas Justice
Role of Pseudogenes in Cancer Stem Creation Via High Nitric Oxide (HNO) Adaptation, Krishi Korrapati '17, Niresh T. Kuganeswaran '16, Thomas Wan '16, Timothy Tamas, and James A. Radosevich
Submissions from 2015
Active Brain Regions During Sleep Using Electroencephalography-Functional Magnetic Resonance Imaging, Grace Duan '15, Sameeksha Malhotra '15, and Todd B. Parrish
Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation, Zachary M. Earley, Suhail Akhtar, Stefan J. Green, Ankur Naqib, Omair Khan '15, Abigail R. Cannon, Adam M. Hammer, Niya L. Morris, Xiaoling Li, Joshua M. Eberhardt, Richard L. Gamelli, Richard H. Kennedy, and Mashkoor A. Choudhry
Using Resting-State Functional Connectivity of the Basal Ganglia as a Biomarker for Symptoms of Parkinson's Disease, Neal Modi '16, Lucy Yuan '16, and Todd B. Parrish
Submissions from 2014
Phthalates and Phthalate Alternatives: Effects on Proliferative and Estrogenic Target Genes in Ishikawa Cells, Ranjani Sundar '15, Ping Yin, and Serdar E. Bulun
The Effect of Small Molecule 390 on CXCR4 Receptors, Selam B. Zenebe-Gete '14, Shruti R. Topudurti '14, Shum Andrew, and Richard J. Miller
Submissions from 2013
Fe, Co and Ni Adatoms Adsorbed on Silicene: A DFT Study, Kent Gang '14, Siva Gangavarapu '14, Matthew Deng '14, Glenn W. "Max" McGee, Ron Hurlbut, Michael Lee Dao Kang, Sean Ng Peng Nam, Harman Johll, and Tok Eng Soon
Metal-assisted etching of silicon molds for electroforming, Ralu Divan, Dan Rosenthal '14, Karim Ogando, Leonidas E. Ocola, Daniel Rosenmann, and Nicolaie Moldovan
Submissions from 2012
Characterization and Manipulation of Nanorods via an Applied Magnetic Field, Summer Wu '13
Comparing Overexcitability Levels between STEM Talented Students and Generally Gifted Students Using the OEQII, Taylor Imburgia '13, Deborah McGrath, and Christopher G. Kolar
Early Events in Herpes Simplex Virus Lifecycle with Implications for an Infection of Lifetime, Sarah Salameh '12, Urmi Sheth '12, and Deepak Shukla
Gold Ion–Angiotensin Peptide Interaction by Mass Spectrometry, Jenny Lee '13, Lasanthi P. Jayathilaka, Shalini Gupta, Jin-Sheng Huang, and Bao- Shiang Lee
The Expression of Ecotropic Virus Integration Site-1 in Seven Cancer Cell Lines, Wendy Bindeman '12
Submissions from 2011
Dopamine Regulation of Cone-Cone Gap Junctions in Ground Squirrel Retina, Xiaoyu Li '12 and Steven DeVries
Flipping the winner of a poset game, Adam O. Kalinich '12
Initial Calibration of CCD Images for the Dark Energy Survey, Deokgeun Park '12, H. Thomas Diehl, and Douglas Tucker